| ABSTRACT
Electrospinning is a method which produces various nanofiber scaffolds for different tissues was
attractive for researchers. Nanofiber scaffolds could be made from several biomaterials and polymers.
Quality and virtues of final scaffolds depend on used biomaterials (even about single substance,
the origin is effective), additives (such as some molecules, ions, drugs, and inorganic
materials), electrospinning parameter (voltage, injection speed, temperature, …), etc. In addition
to its benefits, which makes it more attractive is the possibility of modifications. Common biomaterials
in bone tissue engineering such as poly-caprolactone (PCL), hydroxyapatite (HAp), and
their important features, electrospinning nanofibers were widely studied. Related investigations
indicate the critical role of even small parameters (like the concentration of PCL or HAp) in final
product properties. These changes also, cause deference in cell proliferation, adhesion, differentiation,
and in vivo repair process. In this review was focussed on PCL/HAp based nanofibers and
additives that researchers used for scaffold improvement. Then, reviewing properties of gained
nanofibers, their effect on cell behaviour, and finally, their valency in bone tissue engineering
studies (in vitro and in vivo). |