چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Background: Artemisia splendens from the Asteraceae family is a new source of biologically active compounds. The current study investigated to evaluate antimicrobial and cytotoxicity activity of methanolic extracts and their fractions obtained from aerial parts by agar disk difusion and MTT methods, respectively. The active fractions were subjected to preparative HPLC for isolating the pure compounds, which were structurally elucidated, by 1 H and 13C NMR. Results: The results showed that the methanolic extract and its 60% SPE fraction have the anti-proliferative activity on A549 cell line in comparison with the control group. Meanwhile, the methanolic extract and its 40% SPE fraction can inhibit the growth of Gram-positive strains as anti-microbial activity. The 60% SPE fraction also illustrated anti-proliferative activity on the HT-29 cell line compared to the control group. Chromatographic separations via preparative HPLC yielded 5 favonoids and three favonoid glycosides. Conclusion: Based on the results it can be concluded that A. splendens as a potential source of cytotoxic and antimicrobial compounds can be used in pharmaceutics. Keywords: Artemisia splendens, Anti-proliferative activity, Antimicrobial activity, Cancerous cell lines, Flavonoids |
| نویسنده | نفر چندم مقاله |
|---|---|
| فریبا حشمتی افشار | اول |
| معصومه زاده کمند | دوم |
| عباس دل آذر | چهارم |
| وحیده طرح ریز | پنجم |
| پرینا اصغریان | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Chemical.pdf | 1400/06/06 | 1120198 | دانلود |
