| In spite of all the investigations in the past 20 years that established a great body of knowledge in
cancer therapy, utilizing some elderly methods such as plant compound administration might still
be useful. Curcumin is a bioactive polyphenol, which has many anticancer properties but its capability in modulating miRNA expression has opened new doors in the field of cancer-targeted
therapy. MiRNAs are a class of small noncoding RNAs that are able to regulate gene expression
and signaling. In addition, some other effects of these RNAs such as modulating cell differentiation
and regulation of cell cycle have made miRNAs great candidates for personalized cancer treatment. In this review, we try to find some answers to the questions on how curcumin exerts its
impacts on cancer hallmarks through miRNAs and whether chemotherapy can be replaced by this
beneficial plant compound. |