چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Abstract Aims Coronavirus disease 2019 (COVID-19) is a novel viral infection threatening worldwide health as currently there exists no effective treatment strategy and vaccination programs are not publicly available yet. T lymphocytes play an important role in antiviral defenses. However, T cell frequency and functionality may be affected during the disease. Material and methods Total blood samples were collected from patients with mild and severe COVID-19, and the total lymphocyte number, as well as CD4+ and CD8 + T cells were assessed using flowcytometry. Besides, the expression of exhausted T cell markers was evaluated. The levels of proinflammatory cytokines were also investigated in the serum of all patients using enzyme-linked immunesorbent assay (ELISA). Finally, the obtained results were analyzed along with laboratory serological reports. Results COVID-19 patients showed lymphopenia and reduced CD4+ and CD8 + T cells, as well as high percentage of PD-1 expression by T cells, especially in severe cases. Serum secretion of TNF-α, IL-1β, and IL-2 receptor (IL-2R) were remarkably increased in patients with severe symptoms, as compared with healthy controls. Moreover, high levels of triglyceride (TG) and low density lipoprotein cholesterol (LDL-C), were correlated with the severity of the disease. Conclusion Reduced number and function of T cells were observed in COVID-19 patients, especially in severe patients. Meanwhile, the secretion of proinflammatory cytokines was increased as the disease developed. High level of serum IL-2R was also considered as a sign of lymphopenia. Additionally, hypercholesterolemia and hyperlipidemia could be important prognostic factors in determining the severity of the infection. |
| نویسنده | نفر چندم مقاله |
|---|---|
| عطا محمودپور | اول |
| محمدصادق سلطانی زنگبار | سوم |
| سروین سنایی اسکویی | چهارم |
| لیلی عاقبتی | پنجم |
| سید هادی ثقلینی | ششم |
| زهره استادی | هفتم |
| ژینوس بیات ماکو | نهم |
| مصطفی حاجی فتحعلی ها | دهم |
| زهره بابالو | یازدهم |
| سیما شاه محمدی فرید | دوازدهم |
| لیلا روشنگر | چهاردهم |
| رضا ریخته گر غیاثی | پانزدهم |
| حسین صمدی کفیل | شانزدهم |
| مهدی یوسفی | هفدهم |
| جواد احمدیان هریس | سیزدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Reduction and exhausted features of T lymphocytes under serological.pdf | 1400/05/23 | 1981592 | دانلود |
