چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| AbstractBackground:Nuclear factor-erythroid 2-related factor 2 (Nrf2) plays a key role in promoting chemoresistance in various cancers. PD-L1 is one of the downstream tar-gets of the Nrf2 signaling pathway. This molecule has some beneficial impacts on tu-mors growth by inhibition of the immune system. This study aimed to investigate the potential role of the Nrf2-PD-L1 axis in the promotion of oxaliplatin resistance in colon cancer cells. Methods:We examined Nrf2, PD-L1, and CD80 expression in the tumor and margin tissue samples from CRC patients. After that role of the Nrf2-PD-L1 axis in promotion of Oxaliplatin resistance was investigated.Results:Our data revealed that Nrf2 and PD-L1 mRNA expressions were markedly higher in tumor tissues compared to margin tissues. The PD-L1 mRNA expression level was also increased in the resistant cells. However, Nrf2 expression was decreased in SW480/Res cells and increased in LS174T/Res cells. The inhibition of Nrf2 through siRNA treatment in SW480/Res and LS174T/Res cells has decreased the IC50 values of oxali-platin. Inhibition of the Nrf2 has significantly increased the oxaliplatin-induced apop-tosis, and reduced the migration in SW480/Res cells. Conclusion:It is suggested that effective inhibition of Nrf2-PD-L1 signaling pathways can be considered as a novel approach to improve oxaliplatin efficacy in colon cancer patients |
| نویسنده | نفر چندم مقاله |
|---|---|
| زهرا پاینده | اول |
| عباس پیرپور تازه کند | دوم |
| بهزاد منصوری | سوم |
| وحید خاضع شاهگلی | چهارم |
| میلاد اسدی | پنجم |
| بهزاد برادران | ششم |
| ناصر صمدی | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 545-The Impact of Nrf2 Silencing on Nrf2-PD-L1 Axis to Overcome Oxaliplatin.pdf | 1400/05/16 | 887359 | دانلود |
