Prediction of hypothetical solubility of drugs in phase separated miscible binary solvent mixtures using an interpolation technique
Prediction of hypothetical solubility of drugs in phase separated miscible binary solvent mixtures using an interpolation technique
نویسندگان: الهه رحیم پور , جعفر سلیمانی , ابوالقاسم جویبان
کلمات کلیدی: SolubilityCosolvency modelingSolvent mixturesPhase separationJouyban-Acree model
نشریه: 18106 , 116518 , 335 , 2021
| نویسنده ثبت کننده مقاله |
ابوالقاسم جویبان |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات ایمنی غذا و دارو |
| کد مقاله |
76477 |
| عنوان فارسی مقاله |
Prediction of hypothetical solubility of drugs in phase separated miscible binary solvent mixtures using an interpolation technique |
| عنوان لاتین مقاله |
Prediction of hypothetical solubility of drugs in phase separated miscible binary solvent mixtures using an interpolation technique |
| ناشر |
4 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| Solubility is one of the most important thermodynamic properties in drug discovery, and a major parameter to be considered in pharmaceutics in order to achieve suitable formulations for the desired pharmacological response. It is also an impotant issue in drug re-crystalization and drug extraction using liquid–liquid phase separation. So, the knowledge of solubility in the neat and mixed solvents at various temperatures is neccesary in many pharmaceutical/chemical areas. However, the experimental measurement of this property in all mixture compositions and temperatures is not possible; for example, due to phase separation. In the current study, the applicability of the Jouyban-Acree based models will be investigated for prediction of solubility data in such a solvent mixture using an interpolation technique that provides hypothetical solubility data for these troubled fractions. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| J Mol Liq 335 (2021) 116518.pdf | 1400/05/12 | 1386044 | دانلود |