چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | مرضیه فتحی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات ریز فناوری دارویی |
| کد مقاله | 76464 |
| عنوان فارسی مقاله | Doxorubicin loaded chitosan/gelatin nanogel containing gold nanoparticles as responsive drug delivery for breast cancer treatment |
| عنوان لاتین مقاله | Doxorubicin loaded chitosan/gelatin nanogel containing gold nanoparticles as responsive drug delivery for breast cancer treatment |
| نوع ارائه | پوسترو سخنرانی |
| عنوان کنگره / همایش | همایش کشوری دانش آموختگان نانوفناوری پزشکی |
| نوع کنگره / همایش | ملی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1400 |
| سال انتشار/ارائه میلادی | 2021 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1400/03/06 الی 1400/03/06 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | http://nanograduate.ir/ |
| آدرس علمی (Affiliation) نویسنده متقاضی | Research Center for Pharmaceutical Nanotechnology |
| نویسنده | نفر چندم مقاله |
|---|---|
| مرضیه فتحی | پنجم |
| پروین صمدی پاکچین | اول |
| شقایق اصل زاد | سوم |
| پوریا سوادی صومعه | چهارم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Aim and Background: Chitosan (CS) is a natural polymer. Considering the biological advantages including non-toxicity, biocompatibility, biodegradability, cationic properties, bioadhesive/mucoadhesive characteristics, CS-based particles have been widely studied for delivery of anti-cancer agents, therapeutic proteins, genes, antigens, etc. Considering the various methods of CSNPs preparation, the ionic gelation strategy has been more utilized due to the non-toxic, organic solvent-free, convenient and controllable process. Ionic gelation technique. This method is based on the ionic interactions between the positively charged primary amino groups of CS and the negatively charged groups of polyanion agents, such as sodium tripolyphosphate (TPP) which is the most extensively used ion cross-linking agent due to its non-toxic and multivalent properties. Gelatin, the denatured type of collagen, when mixed by CS form polyelectrolytic complexes with similar structures to the natural components of the ECM, thus providing a suitable environment for enzyme responsive structures. Due to the unique properties of AuNPs, in the proposed project, gold nanoparticles will be synthesized in the presence of CS/gelatin and then nanogel will be prepared via the ionic crosslinking method via TPP. Doxorubicin (DOX) was incorporated within the nanogel cross-linking process and then its release behavior was evaluated in vitro. Method: CS nanogel was synthesized via ionic crosslinking method via TPP. At the first stage, CS/AuNPs were synthesized with CS (1%w/v) solution and HAuCl4, then CS/AuNPs, gelatin and DOX were incorporated within nanogel cross-linking process. Particle size distribution and zeta potential of the prepared NPs were determined by dynamic light scattering (DLS). The amount of loaded and released drug from NPs was analyzed using UV absorbance at different pH values. At different time intervals, an aliquot of medium was removed, replaced with a fresh medium and followed by a UV spectroscopy method. Results and discussion:Natural polymers with outstanding properties alone or in combination with other constituents are valuable biomaterials for the fabrication of advanced multimodal smart nanosystems with the capability for the replacement of conventional cancer DDSs. Figure The DLS analysis confirms the CS/goldNPs/gelatin nanogel formation with a size distribution of about 174 nm, the UV spectrum of CS/gold NPs indicated the peak at approximately 522 nm, typical for surface plasmon resonance in AuNPs. The release behavior at different pHs demonstrated pH-dependent release behavior at 37 ◦C. Conclusion: Compared to classical NPs, nanohybrid responsive DDSs can be utilized as programming treatment via combined photothermal therapy and chemotherapy, which includes the advancement of biomedical, personal health care, and pharmaceutical industries. In this project, the novel nanohybrid systems containing natural polymers as pH as well as enzyme responsive layer and gold NPs as photothermal agent for encapsulation of DOx as potent anti-cancer agents was proposed. The further evaluation of the developed nanosystems for enzyme responsive property, the photothermal effect, and in vitro cellular test are evaluating and will be reported. |
| کلمات کلیدی | Drug delivery systems, Chitosan/gold nanoparticles, doxorubicin |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Lecture 2021.pdf | 1400/05/11 | 560103 | دانلود |
| Poster-Samadi.jpg | 1400/05/11 | 2563183 | دانلود |
| Poster-lecture-Samadi.jpg | 1400/05/11 | 2767628 | دانلود |
