چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The immunosuppressive tumor microenvironment has been implicated in attenuating anti-tumoral immune re-sponses and tumor growth in various cancers. Inhibitory immune checkpoints have been introduced as the primary culprits for developing the immunosuppressive tumor microenvironment. Therefore, a better under-standing of the cross-talk between inhibitory immune checkpoints in the tumor microenvironment can pave the way for introducing novel approaches for treating affected patients. Growing evidence indicates that CD39 and CD73, as novel checkpoints, can transform adenosine triphosphate (ATP)-mediated pro-inflammatory tumor microenvironment into an adenosine-mediated immunosuppressive one via the purinergic signaling pathway. Indeed, enzymatic processes of CD39 and CD73 have crucial roles in adjusting the extent, intensity, and chemical properties of purinergic signals. This study aims to review the biological function of CD39 and CD73 and shed light on their significance in regulating anti-tumoral immune responses in various cancers. |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام باغبانی | اول |
| سعید نورعلیایی | دوم |
| داریوش شانه بندی | سوم |
| امیر علی مختارزاده | چهارم |
| لیلی عاقبتی | پنجم |
| وحید خاضع شاهگلی | ششم |
| شیما رحمانی | هشتم |
| مهدی عبدلی شادباد | نهم |
| امیر باغبانزاده | دهم |
| بهزاد برادران | دوازدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 540-Regulation of immune responses through CD39 and CD73 in cancer.pdf | 1400/05/16 | 3163536 | دانلود |
