چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Inflammation promotes cancer development. To a large extent, this can be attributed to the recruitment of myeloid-derived suppressor cells (MDSCs) to tumors. These cells are known for establishing an immunosuppressive tumor microenvironment by suppressing T cell activities. However, MDSCs also promote metastasis and angiogenesis. Critically, as small non-coding RNAs that regulate gene expression, microRNAs (miRNAs) control MDSC activities. In this review, we discuss how miRNA networks regulate key MDSC signaling pathways, how they shape MDSC development, differentiation and activation, and how this impacts tumor development. By targeting the expression of miRNAs in MDSCs, we can alter their main signaling pathways. In turn, this can compromise their ability to promote multiple hallmarks of cancer. Therefore, this may represent a new powerful strategy for cancer immunotherapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| الهام باغبانی | اول |
| سعید نورعلیایی | دوم |
| شهریار هاشم زاده | ششم |
| امیر باغبانزاده | هفتم |
| بهزاد برادران | نهم |
| آی سان فلاح وزیرآباد | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 530-The impact of microRNAs on myeloid-derived suppressor cells in cancer.pdf | 1400/05/03 | 1546995 | دانلود |
| The impact of microRNAs on myeloid derived suppressor cells in cancer.png | 1400/07/11 | 118111 | دانلود |
