چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| ntroduction.Klebsiella pneumoniae(K. pneumoniae) is one of the leading causes of hospital-acquired and community-acquiredinfections in the world. )is study was conducted to investigate the molecular epidemiology of drug resistance in clinical isolatesofK. pneumoniaein Azerbaijan, Iran.Materials and Methods. A total of 100 nonduplicated isolates were obtained from thedifferent wards of Azerbaijan state hospitals, Iran, from 2019 to 2020. Antibiotic susceptibility testing was done. )e DNA wasextracted, and the PCR for evaluation of the resistance genes was carried out.Results. )e highest antibiotic resistance was shownto ampicillin (96%), and the highest susceptibility was shown to tigecycline (9%), and 85% of isolates were multidrug resistant. )emost frequent ESBL gene in the tested isolates wasblaSHV-1in 58%, followed byblaCTXM-15(55%) andblaSHV-11 (42%). )eqepA,oqxB, andoqxAgenes were found to be 95%, 87.5%, and 70%, respectively. We detectedtetBin 42%,tetAin32%,tetDin 21%, andtetCin 16%. Seventy isolates were resistant to co-trimoxazole, and the rate of resistance genes wassul1 in 71%, followed bysul2(43%),dfr (29%), andsul3 (7%). )e most common aminoglycoside resistance genes wereant3Ia, aac6Ib, aph3Ib, andAPHsin44%, 32%, 32%, and 31.4%, respectively. )e most frequent resistance gene to fosfomycin wasfosA(40%) andfosX(40%) followedbyfosC(20%).Conclusion. )e results of this study indicate the high frequency of drug resistance amongK. pneumoniaeisolatedfrom hospitals of Azerbaijan state. )e present study shows the presence of high levels of drug-resistant genes in variousantibiotics, which are usually used in the treatment of infections due toK. pneumoniae. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مهدی کاشفیه | اول |
| شبنم باغبانی جاوید | سوم |
| رضا قوطاسلو | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| mehdi.pdf | 1400/04/29 | 1453173 | دانلود |
