چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Tinnitus is defined as the auditory phantom perception in the absence of any objective external sound source. In this paper, we used the resting-state electroencephalography (EEG) data to reconstruct the neural sources based on the unit-noise-gain linearly constrained minimum-variance (LCMV) beamformer and applied the effective connectivity analysis on the reconstructed sources to examine the directional neuronal interactions between brain regions in tinnitus patients compared to the healthy controls. We found significantly disrupted patterns of effective connectivity in several brain areas including the frontal, temporal, and occipital cortices as well as the caudate nucleus. Particularly, significant aberrant causal couplings were observed in the orbitofrontal cortex, inferior frontal gyrus_triangular, and parahippocampal region that could potentially illustrate the auditory information retrieval, perception, and evaluation of the phantom sound in the brain of tinnitus patients. Furthermore, topological alterations of the brain network were investigated using graph theoretical analysis. Our findings demonstrated significantly decreased both global integration and segregation of the brain network in tinnitus patients accompanied by the topological shift of tinnitus network to a more random structure in the highfrequency bands. These findings were consistent with the hypothesis of the brain network deviation from smallworldness topology accompanied by reduced global integration in brain-related disorders. |
| نویسنده | نفر چندم مقاله |
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| ناصر صمدزاده اقدم | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
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| Altered effective brain network topology in tinnitus An EEG source connectivity analysis.pdf | 1400/04/05 | 6425081 | دانلود |
