چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| سونیا فتحی کرکان | اول |
| رضا رهبرقاضی | دوم |
| سودابه داوران | سوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Aim and Background: This project’s primary purpose was to create engineered vascular scaffolds using polyurethane, polycaprolactone, and pullulan polymers, along with suitable mechanical-dynamic conditions. Therefore, electrospun scaffolds with optimized intrinsic physiological properties and the ability to support endothelial cells were prepared in vitro, and cell viability was studied in PCL-PU and PCL-PU scaffolds containing pullulan. Methods: The electrospinning method has been used to prepare PCL-PU and PCL-PU scaffolds containing pullulan. The scaffold’s surface morphology was evaluated using SEM microscopic imaging. The scaffolds’ physicochemical properties were prepared using ATR-FTIR, strain stress, water contact angle tests, and the biocompatibility of PCL-PU and PU-PCL-Pl nanofibers was evaluated using the MTT test. Results and discussion: The test results showed that PCL-PU scaffolds containing pullulan have more suitable mechanical properties such as stress-strain, water contact angle and swelling rate, biocompatibility, fiber diameter, and pore size compared to PU-PCL. The culture of endothelial cells under static conditions on these scaffolds did not cause cytotoxic effects under static conditions compared to the control group. SEM images confirmed the ability of endothelial cells to attach to the scaffold surface. Conclusion: The results showed that PCL-PU substrate containing pullulan could stimulate endothelial cells’ proliferation under static conditions. |
| کلمات کلیدی | Vascular tissue engineering, Electrospinning, Nanofiber scaffold, Polyurethane-Polycaprolactone, Pullulan, Endothelial cells. |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 1627896978851.jpg | 1400/05/11 | 104431 | دانلود |
| govahi eraee.jpg | 1400/03/20 | 2539495 | دانلود |
| govahi hozur.jpg | 1400/03/20 | 2494076 | دانلود |
| Preparation of electrospun PCL.docx | 1400/03/20 | 12779 | دانلود |
| ketabche.pdf | 1400/04/27 | 1684823 | دانلود |
| 1(1).docx | 1400/05/05 | 14747 | دانلود |
