| Background: The relationship between sugar-sweetened beverages (SSBs) intake and
serum lipids among children and youth has been reported in several studies, but the
results are still controversial.
Objective: In the current study, we summarized the results of studies that assessed
the relationship between SSBs consumption and serum lipids among children and
youth in a systematic review and dose-response meta-analysis.
Methods: The PubMed, Web of Sciences, Cochrane and Scopus electronic databases
were searched for observational studies reporting an association between
SSBs intake and serum lipids among children and youth that were published
before May 2020. For data extracted from cohort studies, only cross-sectional
baseline data were included in the current meta-analysis. The Random effects
model was used to estimate the pooled weighted mean difference (WMD) and
95% confidence intervals (CI). Heterogeneity was assessed with the Cochran
Q test and I2 statistics.
Results: In our search, 1845 studies were retrieved of which 13 studies (two
cohorts and eleven cross-sectional) were included. High SSB consumption was
associated with 1.21 mg/dL increase in low-density lipoprotein cholesterol
(LDL-C; pooled WMD: 1.21 mg/dL; 95% CI: 0.23, 2.20; P = .01), 1.45 mg/dL
decrease in high-density lipoprotein cholesterol (HDL-C, pooled WMD:
−1.46 mg/dL; 95% CI, −2.25, −0.67; P < .0001) and 2.49 mg/dL decrease in total
cholesterol (TC, pooled WMD: −2.49 mg/dL; 95% CI, −2.89, −2.10; P < .0001). In
dose-response meta-analysis, there was an evidence of departure from linearity
in the relationship between SSB consumption and change in LDL-C
(P-nonlinearity = .03) and TC (P-nonlinearity = .01). However, no departure from linearity
was observed between SSB intake and change in HDL-C (P-nonlinearity = .56) or
triglyceride (TG) values (P-nonlinearity = .85). |