| Various metabolic parameters are risk factors related to the amplified risk of atherosclerotic
cardiovascular disease. A wide variety of data exist on Nigella sativa
(NS) and metabolic parameters. The current study is designed to examine NS supplementation
on lipid profile, blood pressure, glycemic control, anthropometric indices,
and insulin resistance in individuals with coronary artery disease (CAD). In a randomized,
double-blind, placebo-controlled clinical trial, 60 patients with CAD received
either 2 g of NS oil or sunflower oil as a placebo for 8 weeks. Biochemical and
anthropometric measurements were assessed. NS significantly reduced weight
(−1.82 Kg; 95% C, [2.72, 4.13]), body mass index (−0.67 kg/m2; 95% C, [0.33, 1.01]),
waist circumference (−2.15 cm; 95% C, [1.06, 3.23]), hip circumference (−1.26 cm;
95% C, [0.61, 1.910]), waist-to-hip ratio (0.008; 95%C, [0.001, 0.01]), systolic
(−9.52 mmHg; 95% C, [7.14, 11.9]), diastolic blood pressure (−8.26 mmHg; 95% C,
[4.89, 11.62]), and fasting blood glucose (FBS) (−4.32 mg/dl; 95% C, [−0.51, 9.15]) as
compared with the placebo group. The results indicate a potential beneficiary effect
of NS on the metabolic parameters in CAD patients including improvements in
anthropometric indices, blood pressure, and FBS |