چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The equilibrium solubility of a weakly water-soluble drug of naproxen (NAP) in ethylene glycol (EG) + water is determined by a shake-flask method in the temperature range of 293.2–313.2 K. Five models including Jouyban- Acree, Jouyban-Acree-van't Hoff, the mixture response surface, van't Hoff and the modified Wilson models are applied to mathematical modeling of the solubility data. The mean relative deviations is applied for the accuracy investigation of each model. Moreover, the Jouyban-Acree model is used to a numeric representation of the den- sity of saturated mixtures at different temperatures. The respective apparent thermodynamic quantities of the dissolution and solvation processes, namely Gibbs energy, enthalpy, and entropy, are also calculated based on the van't Hoff and Gibbs equations. Further, preferential solvation parameters of NAP by EG molecules are esti- mated based on the inverse Kirkwood-Buff integrals. |
| نویسنده | نفر چندم مقاله |
|---|---|
| میلاد مرادی | اول |
| حسین سیاری کلجاهی | دوم |
| جلال حنائی | پنجم |
| الهه رحیم پور | ششم |
| ابوالقاسم جویبان | هفتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Dissolution thermodynamic study of naproxen in the mixtures of.pdf | 1400/03/05 | 712254 | دانلود |
