چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Because of the extensive biological functions of natural substances such as bio-flavonoids, and their high safety and low costs, they could have high priority applica-tion in the health care system. The antioxidant properties of rutin, a polyphenolicbioflavonoid, have been well documented and demonstrated a wide range of pharma-cological applications in cancer research. Since chemotherapeutic drugs have a widerange of side effects and rutin is a safe anticancer agent with minor side effects sorecent investigations are performed for study of mechanisms of its anticancer effect.Both in-vivo and in-vitro examinations on anticancer mechanisms of this naturalagent have been widely carried out. Regulation of different cellular signaling path-ways such as Wnt/β-catenin, p53-independent pathway, PI3K/Akt, JAK/STAT,MAPK, p53, apoptosis as well as NF-ĸB signaling pathways helps to mediate the anti-cancer impacts of this agent. This study tried to review the molecular mechanisms ofrutin anticancer effect on various types of cancer. Deep exploration of these antican-cer mechanisms can facilitate the development of this beneficial compound for itsapplication in the treatment of different cancers. |
| نویسنده | نفر چندم مقاله |
|---|---|
| امیر ایمانی | اول |
| نسیم ملکی | دوم |
| سپیده بهلولی | سوم |
| مریم کوه سلطانی | چهارم |
| سیمین شریفی | پنجم |
| سولماز ملکی دیزج | ششم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 16952820 (1).pdf | 1400/03/05 | 1153351 | دانلود |
