چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objective: Sumatriptan (ST) is a 5-hydroxytryptamine receptor agonist commonly suggested in the treatment of migraine and cluster headaches. However, the bioavailability of ST is generally poor because of the first-pass metabolism. The present work was undertaken to formulate gastro-retentive microparticles of ST due to enhance the pharmaceutical effect of orally administered ST. Materials and Methods: The ST microparticles were fabricated via the ionotropic gelation technique using sodium alginate (SA) and different ratios of mucoadhsive polymers, namely, chitosan (CS), and carbopol 934P (CP). The developed microparticles were characterized by the production yield, drug loading, entrapment efficiency, size, differential scanning calorimetry (DSC), swelling index, floating capacity, ex vivo mucoadhesion effect, and in vitro drug release. Results: The best formulations (F2 and F’2) exhibited satisfactory physicochemical characteristics. The ST microparticles were detected to be in a micrometer size range. The microparticles exhibited very good percentage of mucoadhesion compared with the SA microparticles. The prepared microparticles had a slower release pattern than the commercial tablet (P<0.05) and the drug release was extended for 8 h. Conclusion: It may be concluded that the gastro-retentive ST microparticles have promising properties and therefore, this formulation is expected to improve migraine management in a better manner. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سلاطین | اول |
| میترا جلوه گری | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 125-Manuscript-1094-1-10-20210220.pdf | 1400/02/31 | 1346607 | دانلود |
