| Porous Metal-Organic Frameworks (MOFs) have emerged as eye-catching materials in recent years. They are
widely used in numerous felds of chemistry thanks to their desirable properties. MOFs have a key role in the
development of bioimaging platforms that are hopefully expected to effectually pave the way for accurate and
selective detection and diagnosis of abnormalities. Recently, many types of MOFs have been employed for
detection of RNA, DNA, enzyme activity and small-biomolecules, as well as for magnetic resonance imaging
(MRI) and computed tomography (CT), which are valuable methods for clinical analysis. The optimal performance of the MOF in the bio-imaging feld depends on the core structure, synthesis method and modifcations
processes. In this review, we have attempted to present crucial parameters for designing and achieving an
effcient MOF as bioimaging platforms, and provide a roadmap for researchers in this feld. Moreover, the influence of modifcations/fractionalizations on MOFs performance has been thoroughly discussed and challenging
problems have been extensively addressed. Consideration is mainly focused on the principal concepts and applications that have been achieved to modify and synthesize advanced MOFs for future applications. |