چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Thermal-responsive magnetic hydrogels (Hydrogel 1 and Hydrogel 2) were synthesized through the copolymerization of maleic anhydride-functionalized Tragacanth gum macromonomer (MATGM), N-isopropylacrylamide (NIPAAm) monomer, and 3-(trimethoxysilyl) propylmethacrylate-modifed magnetic nanoparticles (MPS-MNPs) in the presence of N,N´-methylene-bis(acrylamide) (MBAm) and N,N,N´,N´-tetramethylethylenediamine (TEMED) as crosslinker and accelerator, respectively, using a free radical polymerization approach. The scanning electron microscopy (SEM) images were revealed that the fabricated hydrogels had porous microstructure without microphase separation. The synthesized magnetic hydrogels were loaded with methotrexate (MTX) as an anticancer drug, and their drug loading and encapsulation efficiencies as well as thermal-triggered drug release behaviors were investigated. The biocompatibilities of the fabricated hydrogels were confirmed using MMT assay. The MTX loaded hydrogels were exhibited better anticancer performance than those of the free MTX. Since the biological as well as physicochemical results, the fabricated magnetic hydrogels have high potential for cancer chemotherapy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رعنا جهانبان اسفهلان | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| (65) Jaymand Polym Res.pdf | 1400/02/25 | 3306076 | دانلود |
