چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background: Low oral bioavailability of selegiline hydrochloride (SH) is primarily due to extensive firstpass metabolism and hence the need for an alternative pathway of administration. Materials & methods: Herein, we report the development of sublingual SH films. The films were formulated with varying polymer composition (F1-F6) and evaluated for physicochemical characteristics, in vitro drug release and ex vivo permeation studies. Results: The film F2 demonstrated satisfactory weight (10.60 mg), folding endurance (>200), drug content (11.44 mg/cm2), disintegration time (68 s), mucoadhesive strength (47.7 N/cm2), and controlled release for 30 min. The permeation studies exhibited a higher ex vivo sublingual flux than that of the plain drug. Conclusion: This study concludes that the SH film can provide a potential opportunity for sublingual drug delivery |
| نویسنده | نفر چندم مقاله |
|---|---|
| سارا سلاطین | اول |
| راضیه اسدی دامناب | دوم |
| میترا جلوه گری | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| tde-2020-0118.pdf | 1400/02/06 | 2956731 | دانلود |
