| خلاصه مقاله | Background and Purpose: Mood stabilizers can be divided into traditional agents Lithium, Valproate and carbamazepine and newer or novel
agents, including the anticonvulsants Lamotrigine, oxcarbazepine, topiramate, and gabapentin. The mood stabilizers Lithium and Valproate
have been used to treat children and adolescents with mood and seizure disorders for many years. Current study was conducted to describe
indications, contraindications and side effects of mood stabilizers in children and adolescents.
Methods: A review on relevant databases is done and presented.
Results: Disorders in which Lithium may be use full are: Mania, Bipolar depression, Aggressive behavior in hospitalized children with conduct
disorder, Adolescents with comorbid bipolar and substance use disorders,
Manic symptoms secondary to traumatic brain injury in children, Preventing
recurrent mood episodes in children and adolescents with bipolar disorders, Maintenance treatment in adolescents.
Valproate in children and adolescents, may be effective in the treatment of mania, aggression, and migraine headaches.
In children and adolescents, carbamazepine may be useful for mania, mixed mania, bipolar depression, ADHD, and conduct disorder.
In children and adolescents, gabapentin may be useful as a second or third line treatment, usually for anxiety or sleep disorders comorbid
with bipolar disorder.
Topiramate has been shown to be moderately effective in causing weight loss in adult and adolescent patients with psychotropic – induced
obesity. It has not been shown to be an effective mood stabilizer.
Conclusion: Lithium is the only FDA approved drug for treatment of manic episodes in patients ages 12 years and older. All antiepileptic drugs
increased suicidality risk (About twice). |