چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Aims: Despite extensive efforts to find new treatments, chemotherapy is still one of the first and foremost choices for cancer treatment. The main problems of using these drugs are the resistance of cancer cells and reducing their sensitivity to chemotherapy as well as the side effects of their systemic administration. Because STAT3 plays a very important role in the survival and susceptibility of cancer cells to apoptosis, we hypothesized that sup-pression of STAT3 expression could induce greater susceptibility to DOX-induced cancer cell death. Materials and methods: We used pegylated chitosan lactate nanoparticles (NPs) functionalized by TAT peptide and folate to deliver STAT3 siRNA and DOX to cancer cells simultaneously, both in vitro and in vivo. Key findings: The results showed that NPs could effectively deliver siRNA and DOX to cancer cells, which was associated with suppression of STAT3 expression and increased induction of DOX-mediated cell death. Concomitant delivery of DOX and STAT3 siRNA also suppressed tumor growth in 4T1 and CT26 cancer models, which was associated with induction of anti-tumor immune responses. Significance: These findings suggest that the use of NPs can be an effective strategy for the targeted delivery of STAT3-specific siRNA/DOX to cancer cells |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرناز حاجی زاده | اول |
| وحید کارپیشه | هشتم |
| عطا محمودپور | نهم |
| صنم دولتی | یازدهم |
| مهدی یوسفی | سیزدهم |
| فرهاد جدیدی نیارق | چهاردهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Silencing STAT3 enhances sensitivity of cancer cells to doxorubicin and inhibits tumor progression.pdf | 1400/02/04 | 4552342 | دانلود |
