چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| A new Tc-99m N-doped graphene quantum dot 99mTc-(N-GQD) moiety was developed as a radiolabeling agent for molecules lacking chelation or water solubility of ligands simultaneously. (N-GQDs) were synthesized and characterized with high purity (size range = 5–10 nm). After radiolabeling, ITLC demonstrated that the 99mTc-(N-GQDs) were prepared with high radiochemical purity (RCP Z 95%). Filtration of 99mTc-(N-GQDs) with a 0.1 mm filter proved that 77.38% of the particles were less than 0.1 mm. 99mTc-(N-GQDs) were injected into healthy Wistar rats for biodistribution studies. Results showed that 99mTc-(N-GQDs) were eliminated by the kidneys, and accumulated in the spleen due to the particle size of 99mTc- (N-GQDs). The ovaries and uterus showed a greater concentration of 99mTc-(N-GQDs) within 2 h after injection compared with other organs. Dosimetry studies were done to find out the effective radiation dose of each organ, and introduced the kidneys as critical organs. This research has demonstrated the profound feasible production of 99mTc-(N-GQDs) for possible radiolabeling of molecules with chelation limitations and poor water solubility |
| نویسنده | نفر چندم مقاله |
|---|---|
| اشرف فخاری | دوم |
| اسماعیل قره پاپاق | اول |
| طاهره فیروزیار | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| authorreprints.pdf | 1399/12/27 | 3520562 | دانلود |
