چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| HIF-1α and STAT3 are two of the critical factors in the growth, proliferation, and metastasis of cancer cells and play a crucial role in inhibiting anti-cancer immune responses. Therefore, we used superparamagnetic iron oxide (SPION) nanoparticles (NPs) coated with thiolated chitosan (ChT) and trimethyl chitosan (TMC) and functionalized with hyaluronate (H) and TAT peptide for delivery of siRNA molecules against STAT3 and HIF-1α to cancer cells both in vivo and in vitro. The results indicated that tumor cell transfection with siRNAencapsulated NPs robustly inhibited proliferation and migration and induced apoptosis in tumor cells. Furthermore, simultaneous silencing of HIF-1α and STAT3 significantly repressed cancer development in two different tumor types (4T1 breast cancer and CT26 colon cancer) which were associated with upregulation of cytotoxic T lymphocytes and IFN-γ secretion. The findings suggest inhibiting the HIF-1α/ STAT3 axis by SPION-TMC-ChT-TAT-H NPs as an effective way to treat cancer. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپیده ایزدی | دوم |
| سیما حیدرزاده اصل | چهارم |
| بهزاد بیضایی | پنجم |
| افشین نیک خو | یازدهم |
| مجید احمدی | چهاردهم |
| فرهاد جدیدی نیارق | شانزدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| HIF and STAT3.pdf | 1400/02/04 | 3086121 | دانلود |
