| Endometrial-related disorders including Asherman’s syndrome, thin endometrium, pelvic organ prolapse, and cesarean scar pregnancies can be accompanied by diferent symptoms such as amenorrhea, infertility, abnormal placental implantation and recurrent miscarriage. Diferent methods have been introduced to overcome these problems such as surgery and hormonal therapy but none of them has shown promising outcomes. On the other hand, the development of novel regenerative therapeutic strategies has opened new avenues for the treatment of endometrial-related defciencies. In this regard, diferent types of scafolds, acellular matrices and also cell therapy with adult or stem cells have been investigated for the treatment of endometrial-related defciencies. In this paper, we review the current status of cell-based endometrium regeneration using scafold dependent and scafold-free methods and future perspectives in this feld. Moreover, we discuss the endometrial diseases that can be candidates for cell-based treatments. Also, the cells with the potential for endometrial regeneration are explained. |