چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Idiopathic membranous nephropathy (IMN) as a single organ autoimmune disease is a main cause of nephrotic syndrome in adults which is determined through autoantibodies to podocytes proteins. Th17/regulatory T (Treg) balance has emerged as a prominent factor in the regulation of autoimmunity. In this study, we evaluated the balance of Th17 and Treg cells, expression level of related master transcription factors, cytokines and microRNAs in mononuclear cells of peripheral blood of 30 patients with IMN and 30 healthy individuals before treatment. No significant variation was observed in Th17 cell frequency, retinoic acid receptor-related orphan nuclear receptor γt (RORɣt), signal transducer and Activator of transcription 3(STAT3), IL-17, and IL-23, while IL-21, IL-4, and IL-10 had significant increase in mRNA expression and protein level of peripheral blood mononuclear cells in IMN cases. Reduction in the percentage of Treg cells was also accompanied with significantly decreased expression of Forkhead box P3(FOXP3) and Transforming growth factor beta(TGF-β) in IMN patients compared to the control group. Our study revealed that Th17 cells themselves might not be engaged in the pathogenesis of newly diagnosed patients with IMN; however, decreased T reg cells and increased ratio of Th17/Treg lymphocytes might display a role in the pathogenesis of IMN before treatment. |
| نویسنده | نفر چندم مقاله |
|---|---|
| رزا متولی خیاوی | اول |
| جلال اعتمادی خیاوی | دوم |
| محمدصادق سلطانی زنگبار | سوم |
| محمد رضا اردلان | چهارم |
| هومن کهربا | پنجم |
| لیلا روشنگر | ششم |
| محمد نوری | هفتم |
| لیلی عاقبتی | هشتم |
| سیما عابدی آذر | دهم |
| امیر مهدی زاده حقیقی | یازدهم |
| عطا محمودپور | سیزدهم |
| حسین صمدی کفیل | چهاردهم |
| محمد علی ذوالفقاری | پانزدهم |
| جواد احمدیان هریس | شانزدهم |
| مهدی یوسفی | هفدهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Altered Th17 Treg ratio as a possible mechanism in pathogenesis of idiopathic membranous nephropathy.pdf | 1399/12/24 | 2668219 | دانلود |
