چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده ثبت کننده مقاله | سمانه حسینی |
| مرحله جاری مقاله | تایید نهایی |
| دانشکده/مرکز مربوطه | مرکز تحقیقات علوم اعصاب |
| کد مقاله | 75115 |
| عنوان فارسی مقاله | ارزیابی ضایعات کورتیکال و آتروفی مغزی در مالتیپل اسکلروزیس |
| عنوان لاتین مقاله | Evaluation of cortical lesions and brain atrophy in multiple sclerosis |
| نوع ارائه | سخنرانی |
| عنوان کنگره / همایش | هفدهمین کنگره بین المللی ام اس |
| نوع کنگره / همایش | بین المللی |
| کشور محل برگزاری کنگره/ همایش | Iran (Islamic Republic) |
| شهر محل برگزاری کنگره/ همایش | تهران |
| سال انتشار/ ارائه شمسی | 1399 |
| سال انتشار/ارائه میلادی | 2021 |
| تاریخ شمسی شروع و خاتمه کنگره/همایش | 1399/11/01 الی 1399/11/03 |
| آدرس لینک مقاله/ همایش در شبکه اینترنت | https://iranmscongress.ir/login.aspx?Ph=Personel_Panel.aspx |
| آدرس علمی (Affiliation) نویسنده متقاضی | Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمانه حسینی | اول |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Evaluation of cortical lesions and brain atrophy in multiple sclerosis Cortical lesions, equivalent to juxtacortical lesions could be used to fulfil MRI criteria for dissemination in space. Brain atrophy was included in “no evidence of disease activity” in MS as NEDA4. Pathologically four type of cortical lesion are recognized from mixed GM-WM lesions (type I cortical lesions) to purely intracortical lesions (types II-IV). The whole brain is affected by Global inflammation, extensive cortical demyelination and diffuse axonal injury in the NAWM as early as the disease begin even in clinically isolated syndrome. The volume of cortical lesions and the degree of brain atrophy at baseline and/or continuation are an independent predictor of disability progression and cognitive decline and microglial cells activation are known as effector cells in these processes. Cortical lesions are usually well depicted using 3D T2-FLAIR but may be better detected/localized with some specialized MRI sequences. Progressive loss of whole or regional brain volume can be detected in vivo in a sensitive and reproducible manner by MR imaging, mainly with the use of quantitative measures acquired by automated techniques. These techniques can be classified into 2 broad categories: segmentation-based techniques and registration-based techniques. Segmentation-based techniques enable measurement of whole or regional (eg, gray matter) brain volume at a single time point. Registration-based (Structural Image Evaluation using Normalization of Atrophy (SIENA)) are able to measure changes in whole-brain volume over time by comparing 2 sets of MR imaging scans acquired at different time points. Absence of MRI activity and especially of new/enlarging T2 lesions are associated with less cortical and subcortical GM atrophy. |
| کلمات کلیدی | multiple sclerosis, cortical lesion, brain atrophy |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| scan0001 (5).jpg | 1400/01/21 | 464746 | دانلود |
| Evaluation of cortical lesions and brain atrophy in multiple sclerosis.docx | 1399/11/23 | 20553 | دانلود |
| Evaluation of cortical lesions and brain atrophy in multiple sclerosis.docx | 1399/11/23 | 20553 | دانلود |
