| خلاصه مقاله | Introduction: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system is characterized by impairment of motor and cognitive functions, with a certain degree of overlap. The inflammatory and neurodegenerative changes seen in the brains of MS patients lead to progressive disability and increasing brain atrophy. Plasticity is the ability of the nervous system to adapt to the ever-changing conditions of the environment, encountered during development and learning.
Materials and Methods: We conducted a search in PMC, Science Direct and Neuroscience, PubMed databases. The present information is available reviewing the articles from 1996 to 2020 through the search of the resources.
Results: Within the central nervous system, such plasticity is sustained by a variety of changes in gray matter (e.g., neurogenesis, synaptogenesis, changes in neuronal morphology), in white matter (e.g., changes in the number of axons, axonal diameter, fiber density, axonal branching and trajectories, myelination), and in other tissue compartments (e.g., glial cell size and number, angiogenesis) This Review aims to encourage the transition from characterization of recovery mechanisms to the development of strategies that promote recovery in MS. After initial screening and deleting irrelevant studies,41 studies were chosen for the analysis. Studies were assessed and analyzed methodologically.
Conclusion: The results of the current study, it seems that the neuroplasticity affects the domain of rehabilitation with multiple sclerosis and provides a desirable environment for plasticity-based intervention aimed at motor learning in this population.Large studies with long follow-ups are needed to explain the beneficial effects of neuroplasticity based training combined with rehabilitation protocols. |