سندرم متابولیک و خطر ابتلا به سرطان کولورکتال: یک مطالعه مورد شاهدی

Metabolic Syndrome and Risk of Colorectal Cancer: A Case Control Study


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نویسندگان: حسین عزیزی , الهام داوطلب اسماعیلی

عنوان کنگره / همایش: نهمین کنگره اپیدمیولوژی ایران , Iran (Islamic Republic) , تهران , 2019

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نویسنده ثبت کننده مقاله حسین عزیزی
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه روانپزشکی و علوم رفتاری
کد مقاله 74952
عنوان فارسی مقاله سندرم متابولیک و خطر ابتلا به سرطان کولورکتال: یک مطالعه مورد شاهدی
عنوان لاتین مقاله Metabolic Syndrome and Risk of Colorectal Cancer: A Case Control Study
نوع ارائه پوستر
عنوان کنگره / همایش نهمین کنگره اپیدمیولوژی ایران
نوع کنگره / همایش ملی
کشور محل برگزاری کنگره/ همایش Iran (Islamic Republic)
شهر محل برگزاری کنگره/ همایش تهران
سال انتشار/ ارائه شمسی 1398
سال انتشار/ارائه میلادی 2019
تاریخ شمسی شروع و خاتمه کنگره/همایش 1398/07/30 الی 1398/08/02
آدرس لینک مقاله/ همایش در شبکه اینترنت https://doi.org/10.22037/meipm.v7i3.28786
آدرس علمی (Affiliation) نویسنده متقاضی Research Center of Psychiatry and Behaviors Sciences, Tabriz University of Medical Sciences, Tabriz, Iran

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نویسنده نفر چندم مقاله
حسین عزیزیاول
الهام داوطلب اسماعیلیدوم

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عنوان متن
خلاصه مقالهIntroduction: Among Middle East countries, the prevalence of Metabolic Syndrome (MetS) and Type 2 Diabetes Mellitus (T2DM) were increased dramatically in Iran. Very few evidence based studies have been performed on the relationship between metabolic disorders and Colorectal Cancer (CRC) in developing countries at least in Iran. Objectives: The aim of this case control study was to determine the relation of between MetS and CRC risk. Methods: A 1:1 case–control study with 414 participants (207 cases and 207 controls) was conducted among referral hospitals (Imam Reza, ShahidMadani and Sina) in Tabriz city from Azerbaijan province, Iran. Cases with CRC confirmed by positive pathology and colonoscopy findings were selected and compared with controls free of neoplastic and chronic diseases at the same time and hospitals for the cases. Group matching was used based on sex and age variables for case and control groups. MetS was defined by International Diabetes Federation (IDF) criteria. Multiple logistic regression was used to estimate adjusted odds ratios for the association between MetS and odds of CRC. Results: Out of 414 participants, 220 (53%) were men. Among cases, 134 (64.73%) patients had MetS while in control group, 82 individuals (39.61) had MetS history. After adjusting for the confounders, MetS and DM history were significantly associated with elevated odds of CRC (OR: 2.79, %95 CI: 1.58-5.15, P=0.001) and (OR: 2.57, %95 CI: 1.25-4.58, P=0.006) respectively. We have observed also a dose response relation and a trend between components of MetS and CRC risk. So that, odds of CRC was increased by rising numbers of MetS components. Conclusion: It seems that MetS and its components are associated with increased risk of CRC.
کلمات کلیدیColorectal cancer, Metabolic Syndrome, Type 2 diabetes, Case Control study

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