| خلاصه مقاله | Introduction: MRI as a powerful imaging modality provide high spatial resolution images of soft tissues. However, it suffers from low sensitivity limitation. MRI contrast media used to overcome low sensitivity of MR imaging. Commercial gadolinium chelates have been widely used as contrast materials in clinical MRI. Nowadays, with development of nanotechnology, magnetic nanomaterials have been investigated for contrast enhanced MRI. This study reviews the utilization of the manganese oxide nanoparticles in MRI as contrast material.
Materials and Methods: The search was done using the words of “manganese oxide nanoparticles”, “contrast material/agent” and “MRI” in PubMed, Science Direct, Scopus, ISI Web of Science and Springer data sets during 2010-2020 to identify appropriate studies.
Results: Different types of manganese oxide nanoparticles including MnO, MnO2 and Mn3O4 have been investigated as MRI contrast materials. Manganese oxide nanoparticles are less harmful than their lanthanide partners. In addition, they show rapid exchange rate of water protons. Therefore, because of the relationship of the commercial gadolinium chelates with nephrogenic systemic fibrosis, manganese oxide (MnO) nanoparticles can be considered as an appealing alternative for T1 relaxation time shortening. Hence, they have gotten an alluring subject as T1 contrast material.
Conclusion: Study results demonstrate that manganese oxide nanoparticles have potential for utilization as T1 contrast materials in MRI. |