چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Objectives: To determine the status of primary osteoporosis and evaluate the effects of curcumin nanomicelles, Nigella sativa oil, and curcumin nanomicelles plus N. sativa oil compared to placebo on cellular-molecular and clinical outcomes. Materials and Methods: The study protocol will be implemented in two phases. The first phase is a cross-sectional study aiming at determining the prevalence of primary osteoporosis and its risk factors, especially cellular-molecular factors in 528 postmenopausal women aged 50-65 years in Tabriz, Iran through simple random sampling. The second phase is a triple-blind factorial randomized controlled clinical trial. In this phase, patients with primary osteoporosis, identified with dual-energy X-ray absorptiometry, will be randomly divided into equal four groups of 30 individuals in a triple-blind factorial randomized controlled trial. The four group included N. sativa oil soft capsules (one capsule 1000 mg/d) and placebo- curcumin nanomicelles, curcumin nanomicelles soft capsules (one capsule 80 mg/d) and placebo-N. sativa, N. sativa oil, and curcumin nanomicelles soft capsules, and both placebos for six months. Results: The prevalence of primary osteoporosis and its relationship with several parameters will be determined in phase 1, including socio-demographic-obstetric-medical characteristics, anthropometric indices, body composition, lifestyle, osteoporosis-related microRNAs, inflammatory and oxidative biomarkers, bone turnovers, and some gene polymorphisms. Finally, changes in mean bone mineral density (BMD), bone turnovers, inflammatory and oxidative biomarkers, and esteoporosis-related microRNAs will be evaluated in phase 2. Conclusions: The present study can significantly contribute to the prognosis of the disease and the selection of an appropriate herbal supplement given the cost-effectiveness of herbal compounds as pharmaceutical adjuvants. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سمیه عبدالعلی پور | اول |
| مژگان میرغفوروند | دوم |
| مجید مبصری | سوم |
| سکینه محمد علیزاده چرندابی | چهارم |
| علیرضا استاد رحیمی | پنجم |
| ندا دولت خواه | ششم |
| سید کاظم شکوری بیلانکوهی | هفتم |
| صفر فرج نیا | هشتم |
| عزیزه فرشباف خلیلی | نهم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| pdf_IJWHR_protocole.pdf | 1399/10/26 | 433569 | دانلود |
