چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In novel coronavirus disease 2019 (COVID‐19), the increased frequency and overactivation of T helper (Th) 17 cells and subsequent production of large amounts of proinflammatory cytokines result in hyperinflammation and disease progression. The current study aimed to investigate the therapeutic effects of nanocurcumin on the frequency and responses of Th17 cells in mild and severe COVID‐19 patients. In this study, 40 severe COVID‐19 intensive care unit‐admitted patients and 40 patients in mild condition were included. The frequency of Th17 cells, the messenger RNA expression of Th17 cell‐related factors (RAR‐related orphan receptor γt, interleukin [IL]‐17, IL‐21, IL‐23, and granulocyte‐macrophage colony‐stimulating factor), and the serum levels of cytokines were measured in both nanocurcumin and placebo‐treated groups before and after treatment. A significant decrease in the number of Th17 cells, downregulation of Th17 cell‐related factors, and decreased levels of Th17 cell‐related cytokines were found in mild and severe COVID‐19 patients treated by nanocurcumin compared to the placebo group. Moreover, the abovementioned parameters were significantly decreased in the nanocurcumin‐treated group after treatment versus before treatment. Curcumin could reduce the frequency of Th17 cells and their related inflammatory factors in both mild and severe COVID‐19 patients. Hence, it could be considered as a potential modulatory compound in improving the patient's inflammatory condition. |
| نویسنده | نفر چندم مقاله |
|---|---|
| مجید احمدی | دوازدهم |
| لیلا روشنگر | ششم |
| حامد ولی زاده | پنجم |
| مجتبی ورشوچی فرد | هفتم |
| لیلی عاقبتی | یازدهم |
| آیدین واعظ | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Immunomodulatory effects of nanocurcumin on Th17 cell.pdf | 1400/01/17 | 2869952 | دانلود |
