| The present review provides an overview of recent advances regarding the function of Th17 cells and their
produced cytokines in the progression of viral diseases. Viral infections alone do not lead to virus-induced
malignancies, as both genetic and host safety factors are also involved in the occurrence of malignancies. Acquired immune responses, through the differentiation of Th17 cells, form the novel components of the Th17 cell
pathway when reacting with viral infections all the way from the beginning to its final stages. As a result, instead
of inducing the right immune responses, these events lead to the suppression of the immune system. In fact, the
responses from Th17 cells during persistent viral infections causes chronic inflammation through the production
of IL-17 and other cytokines which provide a favorable environment for tumor growth and its development.
Additionally, during the past decade, these cells have been understood to be involved in tumor progression and
metastasis. However, further research is required to understand Th17 cells’ immune mechanisms in the vast
variety of viral diseases. This review aims to determine the roles and effects of the immune system, especially
Th17 cells, in the progression of viral diseases; which can be highly beneficial for the diagnosis and treatment of
these infections. |