چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The small peptides, as multifunctional biomolecules, can afect some organs and metabolic disorders. The purpose of this experiment was to investigate the efects of some small peptides on the renal enzymes and histopathology in mice exposed to diabetes. Solid phase peptide synthesis method was used to synthesis di- and tri-peptides. Diabetes was induced in mice by multiple injection of low doses of streptozotocin. The efects of the di- and tri-peptides on renal aspartate aminotransferase, alanine transaminase, alkaline phosphatase, superoxide dismutase (SOD), glutathione peroxidase, total antioxidant (TAC), and catalase activities were evaluated by enzymatic biochemical methods and malondialdehyde (MDA) by thiobarbituric acid method. Hematoxylin and eosin and TUNEL stainings performed for assessing histopathology and apoptosis of the mice kidney. Hannaneh (Leu–Gly) and carnosine (Ala–His) exhibited suppression efects on the blood glucose elevation and the severity of the renal alterations in diabetic mice. They showed a decreasing efect on diabetes-induced DNA damage (P < 0.05). Carnosine signifcantly prevented from MDA elevation (P < 0.05). The Pro–Pro showed a supression efect on the blood glucose elevation (P < 0.05). Glutathione (Glu–Cys–Gly) and hannaneh caused to renal tissue TAC decreasing (P < 0.05). Mice receiving Pro–Gly and Pro–Gly–Pro have lesser renal SOD compared to diabetic mice (P < 0.05). Pro– Gly–Pro signifcantly decreased the diabetes-induced DNA damage. Although all the treatments had signifcant efects on alleviating the apoptosis, but carnosine and hannaneh dipeptides had the best protective efect on the kidney. The carnosine and hannaneh dipeptides had higher reno-protective efects against renal enzymes and histologic changes in diabetic mice. |
| نویسنده | نفر چندم مقاله |
|---|---|
| هادی ولیزاده | دوم |
| مهران مسگری عباسی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 193-2020-Renoprotective effects.pdf | 1399/10/07 | 1453481 | دانلود |
