چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Introduction: Although bromocriptine has been approved as an antidiabetic agent, few studies have reported the benefcial effects of other anti-hyperglycemic long acting dopamine agonist agents. In this regard, Cabergoline has fewer side-effects than that of Bromocriptine which can be administered as one or two days per week with higher compliance rates in patients. Aim: To determine the effect of Cabergoline on glycaemic control in patients with Type 2 Diabetes Mellitus (DM). Materials and Methods: In this double-blind clinical trial, initial laboratory parameters including Fasting Plasma Glucose (FBS), 2 Hours Postprandial Plasma Glucose (2HPPG), HbA1c, Total Cholesterol (T-Chol), Triglycerides (TG), and High Density Lipoproteins (HDL) were assessed. The subjects were randomly assigned into two case and control groups. The intervention group received 0.25 mg Cabergoline tablets weekly for the frst 2 weeks and 0.5 mg per week for the next 12 weeks. Control group also received placebo tablets. All clinical and laboratory assessments were repeated 3 months after initial visit. Paired t-test, independent t-test and chi-square were used for the comparison of quantitative and qualitative variables, respectively. Covariance analysis was also used to adjust for confounding variables. p<0.05 was considered as statistically signifcant. Results: HbA1c (p=0.01) and TG (0.04) levels were signifcantly decreased after intervention in the case group compared to the controls. Conclusion: Cabergoline, over a 3 months period, exhibits benefcial effects on HbA1C and TG levels and may possibly be useful as a long-term anti-diabetic drug in patients with type 2 DM. |
| نویسنده | نفر چندم مقاله |
|---|---|
| اکبر علی عسگرزاده | اول |
| ساناز کریمی اول | دوم |
| جلیل هوشیار قراملکی | سوم |
| مرتضی قوجازاده | چهارم |
| علیرضا هادی | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Evaluating_the_Effect_of_Cabergoline_on_Glycaemic_.pdf | 1399/10/06 | 257333 | دانلود |
