چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Immunotherapy methods using potential tumor microenvironment modulators have elicited durable therapeutic responses in cancer treatment. Immune checkpoint molecule programmed cell death-ligand 1 (PD-L1) and oncogenic transcription factor STAT3 (signal transducer and activator of transcription-3) assigned as inhibitory targets of our study and particular delivery system designed to deliver small interfering RNAs (siRNAs) to silence the targeted genes. Generated trimethyl chitosan (TMC) and thiolated chitosan (TC) nanoparticles (NPs) conjugated with HIV-1-derived TAT peptide and HA (hyaluronic acid) exhibited eligible physicochemical characteristics, notable siRNA encapsulation, serum stability, non-toxicity, controlled siRNA release, and extensive cellular uptake by cancer cells. Dual inhibition with STAT3/PD-L1 siRNA-loaded HA-TAT-TMC-TC NPs led to promising results, including significant downregulation of PD-L1 and STAT3 genes, striking suppressive effects on proliferation, migration, and angiogenesis of breast and melanoma cancer cell lines, and restrained tumor growth in vivo. These findings infer the capability of HA-TAT-TMC-TC NPs containing STAT3/PD-L1 siRNAs as a novel tumor-suppressive candidate in cancer treatment. |
| نویسنده | نفر چندم مقاله |
|---|---|
| شیما بستاکی | اول |
| فریبا کارون کیانی | ششم |
| فرزانه بیگی دارگانی | هشتم |
| محسن آکسون | نهم |
| افشین نیک خو | دهم |
| علی مسجدی | یازدهم |
| عطا محمودپور | دوازدهم |
| مجید احمدی | سیزدهم |
| صنم دولتی | چهاردهم |
| فرهاد جدیدی نیارق | شانزدهم |
| نسرین احمدپور صاحب | سوم |
| هدیه جهاندیده | هفتم |
| مهسا افسری کاشانی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Codelivery of STAT3 and PD-L1 siRNA by hyaluronate-TAT trimethyl thiolated chitosan nanoparticles suppresses cancer progression in tumor-bearing mice.pdf | 1399/10/22 | 16324223 | دانلود |
