چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Gastric cancer accounts as one of the most common and poor prognosis malignancies. To investigate the radioenhancer effects of gold, silver, platinum, bismuth, iron oxide, titanium oxide and germanium nanoparticles, we irradiated gastric adenocarcinoma cell lines with 6 MV X-rays in the presence of nanoparticles using Geant4 Monte Carlo simulation along with LEM radiobiological model. The simulated spherical AGS cell was simulated with a radius of 7.72 µm and a 3.72 µm nucleus positioned at cell center. Then radioenhancer effects of 0.05 µM, 0.25 µM and 0.5 µM of the nanoparticles with a homogeneous distribution throughout the cell, including the nucleus, cytoplasm and extracellular matrix were investigated. It was found that the nanoparticles have the potential to be used as radiation sensitizer in the gastric cancer cells with a higher efficiency for heavier nanoparticles and inter nucleus distribution. The survival reduction coefficient was obtained 0.5 for light nanoparticles including 0.5 μM titanium oxide, iron oxide and germanium and also 0.3 to 0.1 for heavy nanoparticles including 0.5 μM gold, silver, bismuth and platinum. Nanoparticle-mediated Enhancement Ratio for 0.5 μM inter nuclear Gold, Silver, Bismuth, Germanium, Platinum, Iron oxide and Titanium oxide nanoparticles was calculated to 0.10, 0.27, 0.26, 0.47, 0.09, 0.50, and 0.58, respectively. Radiosensitization by NPs during radiotherapy may enhance the therapeutic efficacy. |
| نویسنده | نفر چندم مقاله |
|---|---|
| سپهر بتوئی | اول |
| جلیل پیرایش اسلامیان | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Assessment of metallic nanoparticles as radioenhancers in gastric cancer therapy by Geant4 simulation and local effect model.pdf | 1399/09/26 | 2060286 | دانلود |
