چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Surfactants are used frequently as a component of pharmaceutical products. Cationic surfactants used to the formation of cationic nanoparticles (NPs) those present enhanced cellular uptake. With this purpose, first cationic surfactants, Stearylcholine (SC), and Oleylcholine (OC) were synthesized and then their characterization such as critical micelle concentration (CMC), Krafft temperature, and hydrophilic lyophilic balance (HLB) were evaluated. Cationic solid lipid nanoparticles (SLNs) were prepared through the emulsification method. The particle size and Zeta potential (ZP) of SC-SLNs were 93 +/- 0.1 nm and þ38.3 mV. OC-SLNs showed the particle size of 718 +/- 0.1 nm and ZP of þ39.9 mV. Cytotoxicity studies of SLNs and synthesized materials were assessed on human normal HFFF-2 and A549 lung cancer cells. Resultant SLNs showed no cytotoxic effects on HFFF-2 cells. SLNs and synthetic materials showed toxic effects on A549 lung cancer cells. |
| نویسنده | نفر چندم مقاله |
|---|---|
| هادی ولیزاده | پنجم |
| مریم سعادت تازه کند | اول |
| سودا جعفری | دوم |
| پروین ذاکری میلانی | سوم |
| جاوید شهبازی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| saadat2020.pdf | 1399/09/01 | 6703142 | دانلود |
