چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Purpose Periprocedural myocardial injury (PMI) following percutaneous coronary intervention (PCI) has received great attention due to its significant association with mortality and morbidity. Accordingly, cardioprotection during PCI is one of the important therapeutic concerns. Regarding the potential cardiovascular benefits of pentoxifylline this study was performed to evaluate whether the pretreatment pentoxifylline could reduce PMI in patients who are undergoing elective PCI. Methods A randomized clinical trial on 85 patients undergoing elective PCI was performed. The intervention group (n=41) received 1200 mg pentoxifylline in divided doses plus the standard treatment before PCI, while the control group (n=44) received the standard treatment. For assessing myocardial damage during PCI, the levels of CK-MB and troponin-I were measured at baseline, 8, and 24 h after the procedure. Then, patients were followed up for a 1-month period regarding the major adverse cardiac effect. Results Comparing with the control group, no significant change of CK-MB at 8 (p=0.315) and 24 h (p=0.896) after PCI was documented in pentoxifylline group. Similarly, no significant change was found in troponin-I at 8 (p=0.141) and 24 h (p=0.256) after PCI. Conclusions This study could not support the pretreatment with pentoxifylline in the prevention of PMI in patients undergoing elective PCI. However, the trend was toward the potential benefit of pentoxifylline. |
| نویسنده | نفر چندم مقاله |
|---|---|
| ناصر اصلان آبادی | اول |
| صمد غفاری باویل | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| aslanabadi2014.pdf | 1399/08/17 | 209171 | دانلود |
