Gingerly effervescent tablets: investigating the effect of cytotoxicity on gingival fibroblasts and antimicrobial properties under laboratory conditions

Gingerly effervescent tablets: investigating the effect of cytotoxicity on gingival fibroblasts and antimicrobial properties under laboratory conditions


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نویسندگان: زهرا آقازاده , مرضیه آقازاده , حسین صمدی کفیل , پریسا فلسفی , مهدی رهبر

کلمات کلیدی: Antimicrobial; Cytotoxicity Test; Fibroblasts; Ginger.

نشریه: 0 , 6 , 9 , 2019

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نویسنده ثبت کننده مقاله زهرا آقازاده
مرحله جاری مقاله تایید نهایی
دانشکده/مرکز مربوطه مرکز تحقیقات لثه و دندان
کد مقاله 74373
عنوان فارسی مقاله Gingerly effervescent tablets: investigating the effect of cytotoxicity on gingival fibroblasts and antimicrobial properties under laboratory conditions
عنوان لاتین مقاله Gingerly effervescent tablets: investigating the effect of cytotoxicity on gingival fibroblasts and antimicrobial properties under laboratory conditions
ناشر 5
آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ خیر
عنوان نشریه (خارج از لیست فوق) Biointerface Research in Applied Chemistry
نوع مقاله Original Article
نحوه ایندکس شدن مقاله ایندکس شده سطح یک – ISI - Web of Science
آدرس لینک مقاله/ همایش در شبکه اینترنت

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Ginger is a medicinal plant with antioxidant, anti-bacterial, anti-inflammatory and anti-fungal properties. The shape of effervescent tablet is a new form of this product for use as a mouthwash. This study investigated the cytotoxicity and antimicrobial properties of gingerly effervescent tablets under laboratory conditions. In this study, MTT assay was done to evaluate in-vitro gingival fibroblast cytotoxicity during 24, 48 and 72 hours. In addition, the effect of antimicrobial properties on common bacterial and oral fungi was investigated. Pvalue was considered significantly less than 0.05. There was no significant difference between the mean of live cells in groups with 24, 48 and 72 duration (P-value = 0.071). There was no significant difference between ginger group and control group (P<0.05). Minimum inhibitory concentration (MIC) of effervescent tablet was different, ranging from 10 mg/ml for Candidas family to 20 mg/ml for Staphylococcus and 40 mg/ml for negative grams. According to the results, it can be concluded that gingerly effervescent tablets have no toxic effect after 72 hours of exposureto gingival fibroblasts. Its suitable antimicrobial properties for fungi makes it useful for the control of infection and as an ideal mouthwash.

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نویسنده نفر چندم مقاله
زهرا آقازادهاول
مرضیه آقازادهدوم
حسین صمدی کفیلسوم
پریسا فلسفیچهارم
مهدی رهبرپنجم

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