چاپ صفحه |  صفحه نخست سامانه |  نویسندگان |  اطلاعات تفضیلی |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| نویسنده | نفر چندم مقاله |
|---|---|
| علیرضا خبازی اسکویی | اول |
| آیدا مالک مهدوی | دوم |
| عنوان | متن |
|---|---|
| خلاصه مقاله | Background/Purpose : Remission has been introduced as a desirable outcome and the primary target of treatment in systemic lupus erythematosus (SLE). The purpose of our study was to identify the number of patients in remission and the long- term outcome of the disease, and their predictors in a cohort of SLE patients. Methods : Of the 379 patients in our SLE Database, a total of 193 patients fulfilled the inclusion criteria. Remission was definition according to the definitions of remission in SLE (DORIS). Three levels of remission were defined, including remission on- treatment, remission off- treatment and complete remission. In addition, we have defined a sustained remission for each level of remission in which theremission should last at least 5 years. Results : During a median follow- up of 96 months, remission ontreatment and off- treatment, and complete remission were obtained in 88.1%, 38.9% and 13.5% of patients, respectively. Predictors of remission on- treatment in multivariate regression analysis were adherence to therapy and remission induction during 6 months after treatment. Predictors of remission off- treatment were age ≥ 40 at the time of analysis and remission induction during 6 months after treatment. Poor outcome (SLE Damage Index ≥ 1 or death) was observed in 30% of the patients. Age at disease onset < 30, kidney and nervous system involvement, and SLEDAI- 2K >11 at the cohortentry were the risk factors of poor outcome in multivariate analysis. However, sustained remission on- treatment had a negative association with poor outcome. |
| کلمات کلیدی | رمیسیون، لوپوس اریتماتو سیستمیک |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Oral Abstracts.pdf | 1399/08/17 | 1094728 | دانلود |
| 91148023.pdf | 1399/08/18 | 196920 | دانلود |
