Effects of Intravenous Indomethacin on Reduction of Symptomatic Patent Ductus Arteriosus Cases and Decreasing the Need for Prolonged Mechanical Ventilation
Effects of Intravenous Indomethacin on Reduction of Symptomatic Patent Ductus Arteriosus Cases and Decreasing the Need for Prolonged Mechanical Ventilation
نویسندگان: عبدالله جنت دوست , محمود صمدی , سعداله یگانه دوست , محمد حیدرزاده , حسین علیخواه , رضا پیری , محمد نقوی بهزاد
کلمات کلیدی: Indomethacin
Patent Ductus Arteriosus
Hemorrhage
Mechanical Ventilation
نشریه: 42207 , 6 , 2014 Dec , 2014
| نویسنده ثبت کننده مقاله |
سعداله یگانه دوست |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات سلامت کودکان |
| کد مقاله |
74345 |
| عنوان فارسی مقاله |
Effects of Intravenous Indomethacin on Reduction of Symptomatic Patent Ductus Arteriosus Cases and Decreasing the Need for Prolonged Mechanical Ventilation |
| عنوان لاتین مقاله |
Effects of Intravenous Indomethacin on Reduction of Symptomatic Patent Ductus Arteriosus Cases and Decreasing the Need for Prolonged Mechanical Ventilation |
| ناشر |
7 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
Journal of Cardiovascular and Thoracic Research (JCVTR) |
| نوع مقاله |
Short Communication |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
|
| Introduction: We decided to investigate the effects of injecting Indomethacin on reducing
complications of Patent Ductus Arteriosus (PDA) and the need for prolonged mechanical
ventilation.
Methods: During this randomized clinical trial, 70 premature infants with matched gestational
age and birth weight were divided into case and control groups. In the study group, intravenous
indomethacin started from the first 2-12 hours of birth. All patients were followed by
echocardiography at the fourth day and skull ultrasound in the second week.
Results: Symptomatic PDA rate was significantly higher in the control group (25.7% vs. 0%;
P≤0.001). Incidence of grade 1-3 intraventricular hemorrhage was higher in the control group
and the ratio of needed time for respiratory support in the control group to the case group was
approximately 2.1.
Conclusion: Intravenous Indomethacin reduced the number of PDA cases and incidence of grade
2 and 3 intraventricular hemorrhage, without any short term side effects. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| yeganeh.pdf | 1399/10/30 | 217282 | دانلود |