چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Solubility profile for mesalazine in the mixtures of ethylene glycol and water is measured by a shake-flask method at 293.2–313.2 K. Results indicated that the experimental mole fraction solubility of mesalazine in the investigated mixtures increases with increasing the mass fraction of ethylene glycol at a given temperature. Moreover, the mole fraction solubility of mesalazine shows a positive relation with temperature variations as expected. The five solubility models including van't Hoff, the mixture response surface, Jouyban-Acree, JouybanAcree-van't Hoff and the modified Wilson models are applied to correlate the experimental solubility data. The accuracy of the employed models is investigated by computation of the mean relative deviations (MRD%) for back-calculated data. Furthermore, apparent thermodynamic properties of standard enthalpy, Gibbs free energy and entropy of the dissolution process are calculated and discussed. Moreover, by means of inverse KirkwoodBuff integrals, it is observed that mesalazine is preferentially solvated by water and preferentially solvated by ethylene glycol in mixtures of 0.24 < x1 < 1.00. |
| نویسنده | نفر چندم مقاله |
|---|---|
| عاطفه شیخی صوری | اول |
| ابوالقاسم جویبان | دوم |
| سالار همتی | چهارم |
| الهه رحیم پور | پنجم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Solubility of mesalazine in ethylene glycol + water mixtures atdifferent temperatures.pdf | 1400/01/15 | 763837 | دانلود |
