چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| The designing and preparation of a safe drug carrier with sustained and controlled poorly water-soluble drug release ability is valuable in medicine. By considering this aim, magnetic graphene oxide (MG) was prepared through the co-precipitation of the Fe3+ and Fe2+ ions on the graphene oxide (GO) surface. The prepared MG was coated with mesoporous silica (MG@mSiO2). Ibuprofen (IBU) as a poorly water-soluble drug was loaded into the MG@mSiO2 nanosystem and MG@mSiO2-IBU was obtained. MG@mSiO2-IBU showed the burst drug release behavior and released about 86 % of IBU in the first 2 h. To overcome this burst release of IBU, carboxymethyl cellulose (CMC) was used as a coating agent for the encapsulation of MG@mSiO2-IBU. Drug release studies showed that CMC-coated MG@mSiO2-IBU (CMC/MG@mSiO2-IBU) sustainably released the IBU in 8 h with a first-order kinetic model. MG@mSiO2 and CMC/MG@mSiO2-IBU were characterized by using various techniques. VSM analysis displayed the superparamagnetic properties for the CMC/MG@mSiO2-IBU. Based on the MTT and drug release investigation results the prepared CMC/MG@mSiO2-IBU bio-nanocomposite could be proposed potentially as a safe carrier with controlled release of the poorly water-soluble IBU drug |
| نویسنده | نفر چندم مقاله |
|---|---|
| دکتر حسن نمازی | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2020-10.pdf | 1399/07/30 | 3210312 | دانلود |
| RCPN.pdf | 1399/07/30 | 69479 | دانلود |
