Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial
نویسندگان: خلیل انصارین , محمد رضا اردلان , علی تقی زادیه , مجتبی ورشوچی فرد , سهیل تیموری , طاهره واعظی , حامد ولی زاده , سعید صفیری
کلمات کلیدی: Bromhexine hydrochloride COVID-19 disease SARS-CoV2TMPRSS2COVID-19 pneumonia COVID-19 treatment
نشریه: 4594 , 4 , 10 , 2020
| نویسنده ثبت کننده مقاله |
محمد رضا اردلان |
| مرحله جاری مقاله |
تایید نهایی |
| دانشکده/مرکز مربوطه |
مرکز تحقیقات سل و بیماری های ریوی |
| کد مقاله |
74225 |
| عنوان فارسی مقاله |
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial |
| عنوان لاتین مقاله |
Effect of bromhexine on clinical outcomes and mortality in COVID-19 patients: A randomized clinical trial |
| ناشر |
11 |
| آیا مقاله از طرح تحقیقاتی و یا منتورشیپ استخراج شده است؟ |
بلی |
| عنوان نشریه (خارج از لیست فوق) |
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| نوع مقاله |
Original Article |
| نحوه ایندکس شدن مقاله |
ایندکس شده سطح یک – ISI - Web of Science |
| آدرس لینک مقاله/ همایش در شبکه اینترنت |
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| Introduction: Bromhexine is a potential therapeutic option in COVID-19, but no data from a randomized clinical trial has been available. The present study aimed to evaluate the efficacy of bromhexine in intensive care unit (ICU) admission, mechanical ventilation, and mortality in patients with COVID-19.Methods: An open-label randomized clinical trial study was performed in Tabriz, North-West of Iran. They were randomized to either the treatment with the bromhexine group or the control group, in a 1:1 ratio with 39 patients in each arm. Standard therapy was used in both groups and those patients in the treatment group received oral bromhexine 8 mg three times a day additionally. The primary outcome was a decrease in the rate of ICU admissions, intubation/mechanical ventilation, and mortality. |
| نام فایل |
تاریخ درج فایل |
اندازه فایل |
دانلود |
| bi-23240.pdf | 1399/07/30 | 1368944 | دانلود |