چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In this work, a pH-sensitive carboxymethylcellulose based bio-nanocomposite hydrogel beads with different content of layered double hydroxides (LDHs) as a nanoparticle was prepared (CMC/LDH(Cu/Al)). EDX spectroscopy was used to confirm the successful composition of LDH(Cu/Al) with CMC and its presence in the hydrogel matrix. The prepared CMC/LDH(Cu/Al) bio-nanocomposite hydrogel bead characterized by XRD, FT-IR, and SEM analysis. The swelling results showed the pH-sensitive properties for all of the prepared CMC/LDH(Cu/Al). Amoxicillin (AMX) as a model of the antibiotic drug was selected to study the ability of the prepared systems as an oral drug delivery vehicle. The obtained results showed that the CMC/LDH(Cu/Al 7.5) bio-nanocomposite hydrogel bead has a good performance compared to the other prepared bio-nanocomposites. MTT assay approved the safety of this bio-nanocomposite hydrogel bead against HUVEC cells. Consistent with the obtained results, the prepared hydrogel beads could be potentially proposed as an efficient safe drug carrier for AMX oral delivery |
| نویسنده | نفر چندم مقاله |
|---|---|
| دکتر حسن نمازی | سوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| 2020-8 Behzad Nia S ((IJOBIOMAC) 155- 1401-1409).pdf | 1399/07/30 | 3031828 | دانلود |
| RCPN.pdf | 1399/07/30 | 69479 | دانلود |
