چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| In this work, a new pH-responsive nanohybrid carrier was prepared with chelating ZnO-dopamine (Zn-d) on the surface of graphene oxide. Doxorubicin (DOX) as a model drug was loaded on the resulted nanohybrid. The characteristics of Zn-d-rGO nanohybrid (NH) determined using Fourier transformed infrared spectroscopy (FTIR), X-ray Diffraction spectroscopy (XRD), UV–Visible spectroscopy, Scanning Electron Microscope (SEM), EDX and AFM. The BET analysis showed a specifc surface area of 37.16 m2/g and the obtained nanohybrid indicated a high loading capacity of DOX up to 99.7%, and the release profle displayed a pH-dependent discharge in the acidic environment for14 days. The cytotoxicity of the prepared nanohybrid was measured against T47D and MCF10A cells and it confrmed that as-prepared nanohybrid has high toxicity against cancer cells and lower effect against human breast cell. Meanwhile, the prepared nanohybrids showed well antimicrobial activity against gram-positive and negative bacteria. The obtained results showed that the prepared nanohybrid (Zn-drGO) could potentially be used as a safe carrier for drug delivery systems. |
| نویسنده | نفر چندم مقاله |
|---|---|
| دکتر حسن نمازی | دوم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| RCPN.pdf | 1399/07/30 | 69479 | دانلود |
| 2020-1 Alipour 108 110459 Materials Science & Engineering C.pdf | 1399/07/28 | 705732 | دانلود |
