چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| To investigate the anti-inflammatory impacts of piroxicam nanosuspension, in the current investigation, piroxicam:EudragitwRS100 nanoformulations were used to control inflammatory symptoms in the rabbits with endotoxin-induced uveitis (EIU). The nanoparticles of piroxicam:EudragitwRS100 was formulated using the solvent evaporation/extraction technique. The morphological and physicochemical characteristics of nanoparticles were studied using particle size analysis, X-ray crystallography, differential scanning calorimetry (DSC), Fourier transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). Drug release profiles were examined by fitting the data to the most common kinetic models. Selected nanosuspensions were used to assess the anti-inflammatory impacts of piroxicam nanoparticles in the rabbits with EIU. The major symptoms of EIU (i.e. inflammation and leukocytes numbers in the aqueous humor) were examined. All the prepared piroxicam formulations using EudragitwRS100 resulted in a nano-range size particles and displayed spherical smooth morphology with positively charged surface, however, the formulated particles of drug alone using same methodology failed to manifest such characteristics. The EudragitwRS100 containing nanoparticles displayed lower crystallinity than piroxicam with no chemical interactions between the drug and polymer molecules. Kinetically, the release profiles of piroxicam from nanoparticles appeared to fit best with the Weibull model and diffusion was the superior phenomenon. The in vivo examinations revealed that the inflammation can be inhibited by the drug:polymer nanosuspension more significantly than the microsuspension of drug alone in the rabbits with EIU. Upon these findings, we propose that the piroxicam:EudragitwRS100 nanosuspensions may beconsidered as an improved ocular delivery system for locally inhibition of inflammation. |
| نویسنده | نفر چندم مقاله |
|---|---|
| خسرو ادیب کیا | اول |
| محمد رضا سیاهی شادباد | دوم |
| علی نخودچی | سوم |
| علیرضا جوادزاده | چهارم |
| محمد برزگر جلالی | پنجم |
| ژاله برار | ششم |
| یداله امیدی | هشتم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| Piroxicam nanoparticles for ocular delivery.pdf | 1399/07/27 | 416540 | دانلود |
