چاپ صفحه |  صفحه نخست سامانه |  چکیده مقاله |  نویسندگان |  دانلود مقاله | دانشگاه علوم پزشکی تبریز |
| Background:Selegiline hydrochloride (Sel) is a drug applied for the therapy of early‐step Parkinson's disease. In usual clinical doses, it is an elective irreversibleMAO-B inhibitor. This study intended to formulate mucoadhesive microspheres of selegiline with the objective of improving the therapeutic efficacy, patient compliance and bioavailability. Methods:The microspheres were preparedby emulsionsolvent evaporation method (O1/ O2) using hydroxypropyl methylcellulose (HPMC). In the current study, bucco‐adhesive microspheres were prepared with differentdrug to polymer ratios and characterized by encapsulation efficiency, particle size, Differential Scanning Calorimetry (DSC), FTIR Fourier Transform InfraredSpectroscopy (FTIR), flowability, the degreeof swelling and surface pH, mucoadhesive character,retentive time, and drug release studies.Results: The best drug to polymer ratio in microspheres was 1:2 (as F1). The production yield microspheres F1 showed production yield of 84.79%, mean particle size of 744.73 μm and loading efficiency of 53.33%. The DSC exhibited the propertyof selegiline loaded microspheres changed to amorphous form. The FTIR spectrum proposed that the drug kept its chemical stability duringthe emulsification process. The results showed that the microspheres of F1 had faster release than the microspheres of F2 (1:4), F3 (1:6), and commercial tablet (p<0.05). The microspheres did not exhibit good retention time properties (276.66‐329.66 min). The results of mucoadhesionstrength (8.3‐18.3 g/cm2) and surface pH of discs (6.44‐6.97) showed the bettercharacterization of microspheres in buccal. Conclusion:The formulations were found to be appropriate candidates for the improvement of microspheres for the remedial objects |
| نویسنده | نفر چندم مقاله |
|---|---|
| فرناز منجم زاده | اول |
| میترا جلوه گری | چهارم |
| نام فایل | تاریخ درج فایل | اندازه فایل | دانلود |
|---|---|---|---|
| PHARM-24-60.pdf | 1399/07/23 | 821483 | دانلود |
