| خلاصه مقاله | Introduction: Familial adenomatous polyposis (FAP) is a strong risk factor for colon cancer. We aimed to establish coordinated registry of FAP patients and their and improving the prognosis of patients by early diagnosis and prophylactic treatment.
Methods: We included all verifed patients with polyposis and colorectal cancer, through retrieving medical records and active urveillance of FAP clinics, as from 2000 to 2015. Patients were visited by study physicians and their family members at risk were identifed as well. Clinical information has been collected during face to face interview. The registry included information over ascertainment of probands, verifed diagnosis by pathologies and clinical criteria, data over diagnosis and the course of disease, medical and family history; after construction of pedigrees, patients’ relatives were counseled, and screened for the presence of FAP. Newly identifed patients, were invited to FAP clinics for treatment and follow-up. Blood samples and biopsies have been taken for all patients and their relative at risk. Collected data have been digitalized, and was analysis using statistical modules. The study was approved by the Research Ethics Committees, TBZMED.REC.1394.210, of Tabriz University of medical sciences Results: We’ve registered ninety-two patients with FAP (Median age =33 years) and a~50% being female. Bleeding was the most common symptom (62.6%). |